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The complex acts as an inhibitor of apoptosis, has a role in the function of the lymphoid system and may contribute to the in vivo effects of TNF-α.
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Much of the expanding understanding of the lymphoid systems and immunologic functions generated in recent years has been derived from studying patients with primary, generally genetically determined immunodeficiency diseases, as well as other relatively rare secondary immunodeficiency diseases.
The gene, also known as AF4/FMR2, is preferentially expressed on lymphoid cells and encodes a family of transcription factors that are thought to be implicated in the function of the lymphoid system.
It has the function of enhancing the immune responsiveness of the lymphoid system as well as apparently being involved in the body's systemic reaction to infection and injury.
It is clear that Lyn has important functions in numerous hematopoietic cell types, from early stem/progenitors (signaling via the stem cell factor receptor/c-kit [ 27]) through to multiple lineages of the lymphoid system (e.g. B-cell) and the myeloid system (e.g. macrophages, erythroid cells, platelets, mast cells, eosinophils).
The early phase of exploration of the lymphoid system generated a wealth of information about anatomy and in vivo responses.
The murine Mst1 and Mst2 kinases are most abundant in tissues of the lymphoid system.
Tumours of the lymphoid system are very frequent in AT patients.
This clearly suggested that signaling through the death receptor CD95 governs homeostasis of the lymphoid system.
The Bcl-2-family proteins are frequently dis-regulated during oncogenesis, including that of the lymphoid system.
To aid phenotype screening of germ line mutations in the lymphoid system, we developed a method to induce loss of heterozygosity (LOH) in developing lymphocytes through chromosome deletion.
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