Sentence examples for function of the enhancer from inspiring English sources

Function of the enhancer.

We then examined the function of the enhancer in vivo.

Subtle features of this variegation suggest that the function of the enhancer is to decrease the average duration (half-life) of the silent state rather than to increase the duration of the expressed state.

The role of these eRNAs in mediating the function of the enhancer in directing basal gene expression was demonstrated in a recent study for the distal enhancer of the gonadotropin hormone α-subunit gene (Pnueli et al. 2015).

We are currently exploring several avenues of investigation to further understand the function of this enhancer and the ever-increasing complexities of SCL transcriptional regulation.

The second Pbx-Hox and Meis motif cluster appears to be necessary for the general function of this enhancer, as its mutation results in the loss of reporter expression in both hindbrain and neural crest.

This type of enhancer mechanism contrasts what is known about the function of the h7SK enhancer, where optimal transcription efficiency is not dependent upon the presence of an SPH domain [ 29].

However, this new Slou-preferred site was also incapable of mediating the normal function of the mib2 enhancer in Slou-expressing muscle precursors LO1 and VT1 (Fig. 6D), the same effect as produced by either completely inactivating Slou binding (Fig. 4I) or changing the Slou-preferred site to a sequence bound by all HDs (Fig. 6C).

The Mus musculus Igκ locus is regulated by the intronic enhancer (iE/MAR) and the 3' enhancer (3'E), and multiple studies using transgenic and knock-out approaches in mice and cell lines have reported somewhat contradictory results about the function of these enhancers in AID-mediated sequence diversification.

This criterion will miss enhancers such as those described in the previous paragraph: the ancestral function of these enhancers has been conserved but their sequences have become unalignable [ 18].

Sleckman, B. P., Bardon, C. G., Ferrini, R., Davidson, L. & Alt, F. W. Function of the TCR α enhancer in αβ and γδ T cells.