This task is not trivial as potential functions of the docking force fields normally cannot distinguish between target sites unbound and covered with ligands.
We used the "ensemble-flexible docking protocol", a built-in function of the GOLD docking package (version 5.0, Cambridge Crystallographic Data Centre).
While the molecular function of ELMO in the DOCK→Rac signaling pathway still needs to be clarified, it is worth noting that ELMO has functions independent of the DOCK proteins.
The first change is that the dock can now be filled with a bunch of apps — making it look and function like the dock on your iMac.
Several large coiled-coil proteins were also found associated with the cytoplasmic surface of the Golgi apparatus, and two of them have been shown to function in the docking of vesicles to the Golgi cisternae [ 16- 18].
The scoring function of Dock Score indicates that the top three TCM compounds have higher binding affinities than LY2940680.
Both of these aspects of the dock function as one might hope – the card reader reads cards dependably, and the USB 2.0 hub.. hubs.
Our findings demonstrated in vivo a novel function of a Dock family member during demyelination in the CNS.
In this study, we employed the TCM database for virtual screening and ranking the results by the scoring function of Dock score, -PLP1, -PLP2, and H-bond forming residues, H-bond quantity, and Pi forming residues.
The neural function of several Docks, such as Dock5 and Dock8, has not been explored, although the genes encoding these 2 Docks have been shown to link with neurological diseases.,, Therefore, investigations on the synaptic network connectivity and neural behaviors in animals with manipulations of individual Dock genes are important to reveal the physiological roles of Docks in brain.
