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Once candidate genes are identified, functional validation is needed to ascertain the function of the candidate.
And that's just as much a function of the candidate himself and what he's saying and doing – and the people working for him on the ground".
We sought to characterize the potential function of the candidate genes using the human and zebrafish cornea.
Our analyses summarized the landscape of PTSD genetic studies, identified the genes with most genetic evidence, discovered the biological function of the candidate variants/genes and enlarged the overall candidates for future investigations.
Then, the function of the candidate genes in which significant markers were detected was determined using OrygenesDB (http://orygenesdb.cirad.fr/).fr/
represents the common function of the candidate subnetwork.
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An alternative route to look for disease genes, based on the molecular function of the candidates, could be followed.
Because of this, the functions of the candidate genes were tested in vivo in RNAi experiments.
The specific functions of the candidate genes reported in the abovementioned studies are still being validated.
The expression levels and functions of the candidate genes are listed in Table 2.
Therefore, the introgression lines can be used to further examine the functions of the candidate genes identified in our analyses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com