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PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking.
Protein farnesylation is required for the localization and function of several proteins pivotal to signal transduction pathways and cytoskeletal organization, among which are the ras proteins.
Protein farnesylation is required for the localization and function of several proteins pivotal to signal transduction pathways and cytoskeletal organization, including the Ras proteins.
In the 24 mapped structures, the function of several proteins has previously been demonstrated to be affected by nitrosylation.
And S-glutathionylation has been shown to be essential for the function of several proteins such as Ras, NF-1, c-jun, p50/NF-κB, actin and IκB kinase subunit β (IKKβ) [26] [31].
Users of the pipeline are currently applying the ab initio component to deduce the function of several proteins encoded in virus genomes, including the VP24 protein of Ebola and Marburg viruses [51].
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The functions of several proteins of these pathways have been defined, yet new players continue to emerge [ 81– 81].
Protein prenylation is required for the biological functions of several proteins by permitting association with the cell membranes and encouraging protein-protein interactions with other regulatory molecules.
The functions of several protein domains were also relevantly clustered.
Since miRNAs are master switches that ultimately affect complex cellular processes and functions through the regulation of several proteins, miRNA-based therapies may be more effective than drugs targeting single proteins.
PINK1 kinase activity has been shown to regulate the function of several mitochondrial proteins, such as the TRAP1 chaperone protein and the Omi/HtrA2 protease [129,130].
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