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Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial.
Kistner and Weinberg [2004, 2005] describe a retrospective model in which offspring genotype is modelled as a function of offspring phenotype and parental genotypes.
Furthermore, vascular function of offspring born to mothers with higher gestational weight gain was diminished when compared to offspring born to mothers with normal gestational weight gain.
To date, though, only a few studies have examined the impact of both a prenatal and postnatal diet on the vascular function of offspring.
A small number of studies have investigated how a model of maternal over-nutrition impacts the vascular function of offspring [ 13- 15, 17].
To date, two other investigations have examined the impact of a post-weaning diet on the vascular function of offspring [ 14, 17].
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Pulmonary function testing of offspring occurs at 3 and 12 months of age and incidence of wheezing and respiratory illness through 12 months is captured via at least quarterly questionnaires.
It stipulates that physical features and behaviors in offspring of prenatally stressed mothers result from permanent alterations in the structure and function of the offspring's organs and systems, most likely through the impact of maternal cortisol on the fetus' developing HPA axis [ 6].
Thus, we proceeded to study the effect of parental PGC-1 depletion on heart function of the offspring.
Because the sheep pregnancy consists of singleton and twin litters, we sought to determine the impact of ovine twin gestation and twin nursing on the cardiovascular and renal function of the offspring.
It is concluded that interference with the kynurenine pathway in utero can have lasting effects on brain function of the offspring, implying that the kynurenine pathway is involved in the regulation of early brain development.
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