These data are consistent with the in vitro observations that cyclin D1 can be stringently regulated as a function of subcellular localisation (Alt et al, 2000; Radu et al, 2003) and reveal that distinct localisation patterns are observed in prostate cancer.
The main objective of this work was to probe the efficacy of NPs to amplify radiation effects as a function of their localisation in the cells.
While tBRD-1 required tTAF function for nucleolar localisation, localisation of tTAFs, TAF1 and Polycomb to the nucleolus was not visibly altered in homozygous tbrd-1 mutants when analysed by immunofluorescence.
20 Substitution at either the C2 or the C5 carbon atoms (Scheme 1) of the PNA backbone with amino acid side chains leads to ambivalent structures with the properties of a DNA or RNA mimic on one hand and of a peptide mimic on the other, thus allowing recognition by specific receptors, as shown very recently by a short PNA mimicking the function of a nuclear localisation signal peptide (NLS).
It has been hypothesised that the phosphorylation of EGFR may activate Akt phosphorylation, which may subsequently affect the function and localisation of BCRP (Lemos et al, 2008a).
The function and localisation of arthropsin transcripts are unknown and there has been no report of their presence in other arthropods.
It has been reported that the Akt phosphorylation status might affect the function and localisation of BCRP (Lemos et al, 2008a).
There are no published studies on the function and localisation of LPLUNC1, however, proteomic studies have identified it in nasal secretions, bronchoalveolar lavage (BAL) and sputum (Casado et al. 2005; Wu et al. 2005; Nicholas et al. 2006) and shown that it is a major secreted product of cultured tracheobronchial epithelial (TBE) cells (Candiano et al. 2007; Kesimer et al. 2009).
Fluorescence microscopic analysis of tumour tissue, taken 5 min, 2, 6 and 24 h after administration of the compounds, revealed a shifting pattern, as a function of time, in the localisation of labelled lipoproteins and hypericin.
In contrast, with loss of function of Syp, grk mRNA localisation and translational regulation may be disrupted in different ways because loss of Syp could lead to decreased stability of the RNP complex.
