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The methodology assumes that electric spark sensitivity of a nitramine with general formula CaHbNcOd can be expressed as a function of its activation energy of thermal decomposition as well as optimized elemental composition and the contribution of specific molecular structural parameters.
The unit response was then a linear or nonlinear function of its activation.
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It would be reasonable to conclude that the AHR possesses a set of endogenous functions that are independent of its activation as a transcription factor by xenobiotic ligands and that these functions may perform a regulatory role during development.
However, little is known about its function and the molecular mechanism of its activation during liver injury.
Activation of a hidden or output node is a function of its total input activation; the particular function varies with the network.
In the present hypothesis, the intracellular S1P may have pro-apoptotic functions through its activation of Bak and the resulting MOMP.
Mechanistically, these data linked the well-studied DDR signalling pathway and known tumour suppressor functions of its components, including activation of checkpoints and p53-mediated apoptosis and senescence, to an oncogene-induced replicative stress.
While further research into the function of mTORC1 activation and its significance in spinal cord injury is needed, our findings suggest new windows of opportunity for advancing mTORC1 as a possible target for clinical application.
In contrast to its generally accepted role as an oncogene, a growing number of recent studies have demonstrated a growth suppressive function of pSTAT3 due to its activation of genes that inhibit tumorigenesis, including p21 and members of the FOX family of transcription factors [ 68].
It seems that the apoptotic function of EGFR activation is not enough to counter its proliferative, a notion strengthened by the lack of EGFR within the fibrotic lesions.
As a member of the nuclear receptor superfamily, ERα was primarily considered as a transcription factor that controls gene expression through the activation of its two activation functions (ERαAF-1 and ERαAF-2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com