Taken together these results demonstrate that in vivo the main function of integrin β1 in VSCC is to promote cell motility and invasion and that it is not required for activation of FAK, ERK or cell proliferation.
In addition to this structural receptor function of integrins at fertilization (participation in cell-cell and cell-matrix interactions), integrin beta 5 might serve as a signaling receptor that induces serial events (such as inositol lipid turnover and protein phosphorylation) in the sperm, affecting fertilization and early embryo development.
To determine the function of integrin α3 in common glioma cell lines, the endogenous level of integrin α3 in four glioma cell lines was assessed by QRT-PCR and western blotting.
Because of the modulatory potential of ALP on the function of integrins that are crucially involved in leukocyte extravasation [ 5], the present study focused on its interference with leukocyte-endothelial-cell interactions.
The TorsoDβPScyt integrin signaling construct was also able to rescue Race and hnt induction in βPS − embryos, demonstrating that the signaling function of integrins is sufficient for their role in promoting BMP signaling.
Although ILK is thought to primarily function as a downstream effector of integrins in complex with PINCH and parvin (Sakai et al., 2003; Stanchi et al., 2009; Wickström et al., 2010b), ILK can also be regulated by growth factor signaling (Ho and Dagnino, 2012; Serrano et al., 2012) and PI3K/PTEN (Wu and Dedhar, 2001).
The BMP-pathway-enhancing function of integrins is independent of focal adhesion kinase, but it requires conserved NPXY motifs in the β-integrin cytoplasmic tail.
On the other hand, it has been described that at-RA modulates the expression and function of β2 integrins in primary human monocytes [ 11].
Although integrin αv β3 has been shown to be highly expressed in metastatic prostate cancer cells (McCabe et al, 2007, 2008), specific function of integrin αv β3 in prostate cancer metastasis is not clearly understood.
This finding provided a strong evidence for the significance of integrins in the adhesion function of endometrial stromal cells.
