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Using the TRANSFAC® function of GATHER, we identified several transcription factor binding sites that were significantly enriched in the downregulated subset of genes (p-value ≤ 0.003).
The TRANSFAC [ 76] function of GATHER [ 77] (http://gather.genome.duke.edu/) was used to identify enrichment of specific transcription factor signatures within differentially expressed genes.
In fact, the Protein Binding function of GATHER identified a significant enrichment of STAT3 binding partners within the upregulated set of genes and GSEA analysis reported significant overlap between the upregulated genes and gene sets related to IL-6 (interleukin 6), which is an activator of STAT3.
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Further work is needed to develop a multiattribute utility function to gather information on psychometric properties of the PBSI.
Input: Set of gathered requirements.
To investigate the molecular functions of PARP3 and gather some hints about how PARP3 could regulate zebrafish development, we turned to a molecular analysis of PARP3 in the human cell line SK-N-SH.
In that study additional data relevant to cognitive functioning were gathered over many years of follow-up and when combined explained a larger part of the variance.
Decision rules are derived by expressing WH as functions of wind data gathered by the National Data Buoy Center NDBCC).
The automated annotation pipeline at the J. Craig Venter Institute (JCVI) was employed to identify genome features in the raw DNA sequence, gather evidence for function of the features, and assign functional annotation.
Additional evidence about brain functioning is gathered by observing the performance of people whose brains have been damaged in identifiable ways.
The primary function of the PathText Integrator is to gather information from pathway model files, generate queries that can be interpreted by various TM tools and store the results from these queries in a repository.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com