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In some cases, the generation of meaningful immunotoxicology data can be adversely affected by the choice of a species that does not adequately share the immune function of concern with man.
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The potential for this class of compounds to interfere with immune function is of concern; an increase in upper respiratory infections has been reported (34).
Respondents recognised that they often elicited unwanted side effects with effects on cognitive and bowel function of particular concern.
When it is functioning, "Minds of Concern" resembles a slot machine.
The major function of SH4 concerning seed shattering has been illustrated by the analyses of RT-PCR and in-situ hybridization in the seed-pedicel junction region (Li et al. 2006b, Zhou et al. 2012).
This leads to a twofold decrease in the affinity for Hsp70 and decrement of the in vivo function of Hop concerning GR activation.
The recent discovery of cerebral gadolinium deposition in patients with normal renal function is also of concern, although the clinical significance of this phenomenon is yet to be determined [53].
The known regulatory functions of CD45 concern the activation threshold of the TCR-dependent signal, the magnitude and nature of cytokinic responses, and lymphocyte fate [27].
85, 87 Preliminary findings suggesting that cathepsin K appears to be involved in thyroid hormone synthesis, blood pressure regulation, and certain brain functions are also of concern for the long-term use of anti-osteoporotic cathepsin K inhibitors.
It may also be a function of the participants' concern about the prevention of breast cancer generally.
Exacerbation of the renal function should also be of concern because of the high proportion of patients with renal insufficiency diagnosed in this study.
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