Sentence examples for function of atm from inspiring English sources

73– 76 Reactive oxygen species can directly activate ATM, which in turn promotes antioxidant responses through stimulation of the pentose phosphate pathway, and ATM plays a role in monitoring mitochondrial quality control, again pointing to a central function of ATM in controlling cellular metabolism of reactive oxygen species.

We hypothesize that a function of ATM is to act as a redox modulator.

It is conceivable that loss of function of Atm could increase aggressiveness at later stages of tumorigenesis.

Altered function of ATM plays pathologic roles in the development of leukemia/lymphoma and cancer including leukemia with MLL translocations [10], [11].

Hence, the most studied function of ATM is its role in response to DNA damage.

An equally important function of ATM is in effectively repairing DNA double-strand breaks.

Consistent with the tumor-suppressive functions of ATM, we hypothesized that ATM activation might be a general strategy for chemosensitizing resistant tumors to the cytotoxic effects of DNA-damaging therapies.

These functions of ATM are likely through its ability to control the transcription of key regulators, including IL-8, that promote cell migration and invasion to influence metastatic colonization.

Further laboratory research will be needed to determine the function of cytoplasmic ATM and the significance of the translocation process to ATM function in response to genotoxic stress.

The central role of ATM in cell regulation suggests that a loss of function mutations in the ATM gene should result in broadly pleiotropic effects.

Furthermore, the absence of genetic interaction with Atm mutant mice is consistent with cohesin functioning downstream of Atm signalling [15], [23], [44].