Sentence examples for function of a niche from inspiring English sources
The main function of a niche probably is to provide specific factors necessary for the maintenance of the stem cell properties via a combination of intracellular and intercellular signalling.
But, on top of utilitarian functions, this technological future could offer even more experimental and bespoke objects that function on a niche level.
This 'nutritive' function of the niche remains a formal possibility, but in most systems few experimental data in support of it have so far emerged.
In some tissues, this is achieved by the function of a definitive stem cell niche.
Several reports have shown that a hematopoietic environment comprised of stromal cells functions as a niche to support hematopoietic cells.
Range size and ecological niches are linked because the geographic range that any species occupies is a function of its ecological niche, the set of environmental tolerances and limits in multidimensional space that determine where a species in potentially able to maintain populations (Hutchinson 1957; Lomolino et al. 2006).
To maintain stemness, Lgr5+ stem cells require niche factors provided by surrounding cells such as nearby Paneth cells and myofibroblasts underneath the epithelial lining, and the function of these niche factors regulate diverse signaling pathways such as Wnt, BMP, and EGF (Crosnier et al., 2006).
An important function of the niche is to regulate precisely the balance between self-renewal and differentiation in order to maintain optimal organ function at all times.
Recent results provide evidence, that the supportive function of the niche is modified during the process of aging, thereby affecting the extrinsic mechanisms of stem cell control [25].
What are key steps in this evolution, and how does the form and function of the niche change as the niche matures?
Studies on different model organisms indicate that the primary function of GSC niche signal is to prevent premature entry into meiosis/differentiation.
