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Molecular Function: nucleotide binding (D40 ), transcription factor activity (D41 ), protein binding (D48 ), electron carrier activity (D52 ), transporter activity (D55 ).
Among the top-ranking GO categories we identified were GO Molecular Function "nucleotide binding" (n = 20, P = 0.005), "DNA metabolic process" (n = 6, P = 0.043) and "DNA replication" (n = 4, P = 0.032).
Among the molecular function classification class, the enzyme activity, transferase activity, binding activity, hydrolase activity, molecular function, nucleotide binding and protein binding categories included the majority of detected matches.
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Furthermore, the observed loss-of-function nucleotide diversity in East Asia and Oceania was significantly lower than the expected value (θ of 4.8 × 10−4; Tajima's D of −1.64, P <0.01).
In contrast, the ratio of πLOF to πnon-LOF variants in Native Americans was very high, but the difference between the observed and expected loss-of-function nucleotide diversity was not significant (Table 3).
Four GO terms for molecular functions, nucleotide binding, receptor activity, protein binding, and kinase activity, were commonly found among both monoallelic expression and preferential allelic expression genes (Table 1 and Additional file 15: Tables S11 and Additional file 16: Table S12).
Nearly all of these folds converge on four basic functions: nucleotide-phosphate transfer, RNA binding, protein binding, and RNA modification.
Further, gaps in the aligned sequences due to limited dataset were removed on the basis of probability function of nucleotide occurring at the particular position using Gene Runner version 3.05 nucleotide windows and stored as the relational database.
Nonmelanoma skin cancers (NMSC) has been evidenced with an impaired function in nucleotide excision repair (NER).
DDB2 and the Cockayne-syndrome A protein (CSA) function in nucleotide excision repair, whereas the remaining receptors operate in a wide range of other biological pathways.
The analysis using DNAzymes provides a new tool to easily identify ribose methylations in rRNAs and will help to unravel the physiological function of nucleotide modifications.
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