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The possibility of divergence of function is suggested by the large variation in pIs among the proteins (3.98 to 5.59).
A link between viral load and impaired neural function is suggested by a recent study in non-human primates indicating that monocytes may be the link between HIV-1 in the periphery and HAD.
An association of increased paternal age with immune function is suggested by a common link between increased paternal age and mental disorders such as schizophrenia, bipolar disorder, and autism, and the association of these disorders with a common set of immune abnormalities that includes increases in pro-inflammatory cytokines, IL-1beta and IL-6 [48], [48].
The significance of E-cadherin for epithelial cell function is suggested by the fact that malignant transformation frequently coincides with the loss of E-cadherin function [ 20].
Next to muscle mass-dependent changes in muscle function, as described by Weber et al (2008), also muscle mass-independent loss of function is suggested by presented data.
The importance of the N-terminus for chemokine function is suggested by the 'two-step' model of chemokine ligand binding and receptor activation (Fernandez & Lolis, 2002).
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This function was suggested by Wenk et al. (1990, p. 159).
A clue to a potential function was suggested by work investigating mechanisms of biofilm detachment.
In addition, further layers of complexity in REST-CoREST-nuclear receptor regulation and function are suggested by the recent finding that Nr2e1 participates in a dual negative transcriptional feedback loop with the microRNA, miR-9 [85], which also has similar transcriptional regulatory relationships with REST and CoREST [16], [86].
A link between CCK and memory function was suggested by the discovery of CCK-positive neurons in the hippocampus.
Its role in JNK function was suggested by studies showing that MEKK2 gene disruption inhibits JNK activation in mast cells in response to c-Kit and Fcε RI stimulation [ 34].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com