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This differential change in function is operative in both human and mouse macrophage systems and affects cholesterol homeostasis.
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Based on these data, it can be hypothesized that a 'sentinel' function of synovial fibroblasts [ 10] is operative even in the preclinical phase of RA and leads to the initiation and early perpetuation of the disease.
"The mechanism that this study provides for estrogen-mediated decreases in NK cell function may also be operative in the decreases in NK function that have been observed with certain environmental estrogens, such as DDT," says Margaret Whalen, an associate professor of chemistry at Tennessee State University who has studied the immune-suppressive effects of various organochlorine pesticides.
Since the PR includes four items from the function subscale of the WOMAC, it would be expected that it classifies at risk those patients whose pre-operative function is severely affected, considering that pre-operative function has been consistently identified as a determinant of functional outcome [ 12].
The fact that four questions are related to pre-operative function is consistent with the literature where pre-operative function is a major determinant of post-operative function [ 12].
Patients with normal pre-operative renal function were mostly operated for isolated CABG, whereas only a minority (10.0%%) underwent combined surgery.
Post operative function is determined by regaining the optimal strength in this muscle and many rehabilitation programmes include strengthening of gluteus medius.
Also, it has been well demonstrated that pre-operative function is predictive of long-term function.
If the patient is resectable, pre-operative assessment of postoperative liver function is mandatory.
Operative removal is the procedure of choice when function is reduced and the nature of the tumor uncertain.
Postoperative anal function was preserved, and the operative scar was fine and inconspicuous (Fig. 5a and b).
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