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Investigation into such age-related differences in TLR function is of critical importance for the design of effective vaccines that will protect the elderly against infectious diseases.
The accurate assessment of liver function is of critical importance in the management of patients with hepatocellular carcinoma (HCC) [1].
Accurately assessing and monitoring renal function is of critical importance in patients with diabetic nephropathy.
This indicates that the KDM-Jmj hydroxylases are not necessarily involved as on-off switches (as found, for example, in the kinase-phosphatase paradigm of signal transduction), but support other roles, highlighted by the fact that a scaffolding function is of critical importance in various settings, (e.g., as observed for JARID2 or the KDM6 enzymes).
The extent to which these effects apply to the clinical situation has yet to be determined, but given that acidosis is an extremely common problem in the intensive care unit, and immune function is of critical importance, efforts to elucidate these relationships are quite justified.
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Hand and finger functions are of critical importance for independence in everyday activities, but their recovery is often limited following neurological injury, motivating the need for novel therapeutic and assistive tools.
In automotive engineering, the wheels are one of the most critical components and their function is of vital importance n human safety.
Given the changes in serum protein concentrations that occur during tissue repair, inflammation and its resolution, understanding the effects of serum on the differentiation and function of fibrocytes is of critical importance.
It is the chief organizing centre of most ecosystem functions, and it is of critical importance in agricultural science and ecology.
Because the role of EDHF is of critical importance for endothelial function, when NO production is compromised [ 31], we investigated the effect of nor-NOHA on EDHF production by incubating the rings with apamin and charybdotoxin.
Thermodynamics indicates that the higher the temperature, the greater the efficiency of the conversion of heat to work; therefore, the development of materials for combustion chambers, pistons, valves, rotors, and turbine blades that can function at ever-higher temperatures is of critical importance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com