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We conclude that NF-κB transcriptional function is not sustained in activated CD4+ T cells from the elderly, thereby correlating closely with the biochemical assays of NF-κB induction.
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Unfortunately, the currently available therapies designed to improve cognition (i.e., for AD and other forms of dementia) are limited by modest efficacy and adverse side effects, and their effects on cognitive function are not sustained over time.
Available data suggest that in established diabetes effects on β-cell function are not sustained following withdrawal of active therapies; whether this is true at earlier stages of diabetes or in prediabetes is unknown.
The GLP-1 agonists have some effect on beta-cell function, but this is not sustained after the drug is stopped.
This behavior results mainly by the accumulation of H2O2 as a function of enzymatic concentration, whereas the delivery of H2O2 in a single pulse is not sustained.
But it is not sustained.
The charge is not sustained.
Although vitamin E improved resolution of steatohepatitis and ballooning, it did not improve the overall fibrosis score, and liver function improvement was not sustained after the first year.
It's too time-consuming; the primary goal is not sustaining the land but sustaining themselves.
There is some evidence for a short term benefit of NSAIDs (2 weeks) with a decrease of pain and function, but this benefit was not sustained [ 31, 32].
After cessation of therapy, the beneficial effects on β-cell function, glycemic control, and body weight were not sustained, suggesting that active treatment is necessary to maintain these beneficial effects of exenatide in patients in whom oral blood glucose lowering therapy has failed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com