In cells in which p16 function is lost, the transition from G1 to S is not slowed.
In the eulamellibranch ctenidium the filaments and lamellae are closely united, the selection function is lost, and gill structure varies widely.
Dissociation is said to occur when one or more mental processes (such as memory or identity) are split off, or dissociated, from the rest of the psychological apparatus so that their function is lost, altered, or impaired.
Furthermore, despite widespread degenerative neuronal pathology throughout the spinal cord in this model, hindlimb motor function is lost before forelimb function.
The latter type is associated with more minor signs; pneumothorax is small if it occurs at all, and although function is lost in the part of the lung supplied by the injured bronchus, unaffected parts of the lungs may be able to compensate.
Our results suggest that UBIAD1 protein function is lost or decreased by SCD mutations.
Again, this is consistent with the behavior of real proteins, which tolerate conservative substitutions in substantial numbers before function is lost completely [6], [32].
Nonsense codons inserted closer to fur's 5' end exhibited the mild decrease in Mtz resistance characteristic of simple null (deletion) alleles, which would be explained if all Fur function is lost in these shorter remnants, and/or if remnant proteins are degraded.
However, the pericardial edema, loss of blood circulation and tail malformations observed in both sept9a morphant and OE embryos are also consistent with defects in osmoregulation observed when epidermal barrier function is lost [23] or if fish are exposed to toxins that impair homeostasis of the skin or kidney [24], [25].
CTN have been used as a conventional biomarker that predicts several important health outcomes, to diagnose acute kidney injury involving the measurement of levels of serum creatinine, blood urea nitrogen, and urinary enzymes, all of which are elevated after substantial kidney function is lost [8].
