Moreover, the cis and trans forms appear to have entirely different regulatory functions: the cis isomer is locked in a configuration that tethers the SH3N, preventing ligand binding, while the trans configuration appears extended and flexible.
In some cases, the joint is locked using a drop lock, spring loaded lock, cam lock, ball lock, dial lock or a plunger type of lock.
We know the door is locked.
The separation of parasitic elements from cooperators would be cemented by the emergence of physical linkage of the latter: genes that encode components of the replication machinery and are physically linked to genes for accessory functions would be locked into ensembles of cooperators, whereas solitary genes (or small gene arrays) encoding replication functions would occupy the parasitic niche.
For too long, his screen has been frozen, his functions have been locked up and his circuits have been in a cramp just as the Knicks need to be sharpening their preparations for the playoffs.
To test whether epsin could support CCV budding independently of dynamin, we tested the potential rescue by slight overexpression of epsin in two situations where dynamin function was impaired: when dynamin was locked at the neck (using the small-molecule dynamin inhibitor dynasore) and when dynamin was depleted (dynamin1 and 2 [DNM1+2] RNAi).
It looks like they've made the middle buttons programmable, which is a good change from the X8, where they were locked into their functions.
If it says "Lock" and "Clean," the self-cleaning function has been activated and it should be locked for several hours.
30 31 Consequently, these oncogenic Ras mutant proteins are locked in the active, GTP-bound state, leading to constitutive, deregulated activation of Ras function.
