Sentence examples for function is largely dispensable from inspiring English sources

Remarkably, morpholinos targeting the gli2a transcript are able to suppress the yot phenotype fully, not only demonstrating their efficacy but also implying that Gli2a function is largely dispensable in the zebrafish (Karlstrom et al., 2003; Wolff et al., 2003).

We demonstrate that CD103 is largely dispensable for large intestinal immune responses in vivo.

Together with the observations made in Jurkat cells, these data suggest that the third ITAM is largely dispensable for CAR function.

We show herein that the UBL motif is largely dispensable for the functioning of Usa1 in ERAD-L substrate degradation.

Consistent with the idea that sequence-specific DNA binding is largely dispensable for most of MYC's transactivation function, the Price laboratory reported that the positions occupied by the MYC-MAX dimer across the human genome correlate with the Pol II transcription machinery rather than E-box elements (Pufall and Kaplan, 2013).

In contrast, the p53/PUMA/p21 axis has a key role in the survival and regeneration of ISCs following radiation injury, but is largely dispensable for ISC survival and homeostasis.

tud is necessary for germline specification but is largely dispensable for abdomen formation [11], [12].

We conclude that Geminin is largely dispensable for most of embryonic and adult mammalian neurogenesis.

We conclude that Geminin is largely dispensable for adult neurogenesis and for embryonic neurogenesis after e14.5.

Nevertheless, our results clearly indicate that Geminin is largely dispensable for mammalian neurogenesis.

While STAT3 is critical during early embryogenesis, it is largely dispensable in the majority of adult cell types which makes it an attractive therapeutic target [16], [17], [18].