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Conformational sampling by direct optimization of an all-atom energy function is ineffective and inefficient because of the ruggedness of the energy landscape.
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Standard immunosuppression, designed to target T cell immune function, is largely ineffective against this B cell-driven process.
In this context, while neutralization of TNF-α had been shown to be protective in animal models of TSS [16], clinical studies have shown that antagonizing the biological functions of TNF-α is ineffective during sepsis/TSS in human patients and might even be counter productive [17].
None of these considerations necessarily imply that the use of inhaled corticosteroids is ineffective in terms of function.
These findings suggest that either the physiologic parameters studied are not predictive of functional outcome or the scoring system used is ineffective in determining function.
We show that the variability function could be ineffective for queueing networks with splitting and superposition and propose a new decomposition method based on the variability function and the innovations method.
Attenuation of neutrophil migration may be of benefit in treating hyperacute stroke, but previous trials assessing compounds that inhibit neutrophilic function have been ineffective (Krams et al., 2003).
However, wheel running is ineffective at improving motor function (Resedal et al. 2002).
However, this methodology is ineffective for examining cognitive function and potentially yields useless data.
Sales management is ineffective.
It is ineffective.
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