Sentence examples for function is inactivated from inspiring English sources

A typical feature of a classical TSG is that its function is inactivated in different tumors.

Wing disc cells that express GFP and RNAi constructs targeting both ph and Abd-B, sorted-out and were extruded basally from the wing disc epithelium (Figure 8F F″, G G"- arrows) thus resembling the phenotype when only ph function is inactivated.

p53 function is inactivated in up to 80% of HNSCC [ 25].

Moreover, it is not clear how Sgo function is inactivated and whether this is distinct from delocalization.

PARP is a protein that is involved in DNA repair, but the repairing function is inactivated by its cleavage, which thereby contributes to apoptosis and c-PARP is thus an established marker of cells undergoing apoptosis.

As a result, the prodomain's inhibitory function is inactivated and the mature, proteolytically potent enzyme is generated.

When the p16/Rb and p53 functions are inactivated, the cells overcome M0 and M1.

For example, Ubx (Ultrabithorax) mutant embryos have their T3 and A1 segments transformed into T2, as if both the abx/bx and bxd/pbx segment-specific functions were inactivated in Ubx alleles.

In addition, it is possible that calmidazolium, which is marketed as a calmodulin inhibitor, induced the T. gondii phenotype by interfering with P-gp function, as Pgp is inactivated by calmodulin antagonists [41].

Thus, it would be important to determine whether the function of p53 is inactivated in MM cells and to investigate their response to p53 activating agents.

In line with its suppressive function on oncoproteins, SCFFbxw7/hCdc4 is inactivated by mutations in various tumor types [ 4].