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4 Its pro-apoptotic function is exerted through binding and cleavage of IAPs (Inhibitor of Apoptosis Proteins) upon its release into the cytoplasm following a pro-apoptotic stimulus.
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However, few studies have addressed the molecular mechanisms through which such important function is exerted.
It is attractive to speculate that the tumour suppressive function of IKKα is exerted through this pathway as well.
Targeting the HIF pathway has therefore become the focus of efforts to develop small-molecule inhibitors.[ 2] However, HIF's function as a transcription factor is exerted through protein protein interactions (PPIs).
The most prominent therapeutic effect of MSCs is exerted through their immunoregulatory functions.
Selective deposition of methyl marks is exerted through different mechanisms.
Btg antiproliferative function can be exerted through the inhibition of cyclin D1 at the transcriptional level.
From previous studies [3], [6], [7], [29] we hypothesized that a protective mechanism against the NO-mediated negative effects on β-cell function in GK rats might be exerted through the cyclic AMP system.
The regulatory function of subolesin in gene expression may be exerted through interaction with other regulatory proteins at the transcriptional level (Fig. 8).
Accordingly, the effect of thrombocytopenia on CLD progression among HCV and/or Schistosom- infected patients might be exerted through alterations in T-cell functions and activity.
Memory control can be exerted through retrieval suppression.
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