Normal thymic function is critical for immunity and microenvironmental defects predispose to dysregulation in the T cell compartment.
Interestingly, preclinical data both in vitro and in vivo suggest that CDK function is critical for KRAS tumorigenesis and that inhibition of CDK in KRAS mutant NSCLC leads to potent synthetic lethality [42].
Knowledge of function is critical for selecting objects to meet action goals, even when the affordances of those objects are not mechanical for instance, both a painting and a vase can decorate a room.
This specialized detox function is critical for thyroid health.
Androgen receptor (AR) function is critical for the development of male reproductive organs, muscle, bone and other tissues.
For any such problem, proper definition of the target or the objective function is critical for steering the optimization towards global minimum.
Thus, mitochondrial function is critical for the energy production through glycolysis and TCA cycle pathways in cumulus cells and thereafter energy supply for oocyte maturation.
This model is supported by evidence that elg1 deletion exacerbates mcd1 mutant phenotypes, indicating that Elg1p function is critical for the ultimate maintenance of sister chromatin pairing.
Pdx1 is expressed in the region of the endoderm that ultimately gives rise to stomach, pancreas and duodenum and its function is critical for posterior foregut development [4].
Hence, knowledge of which proteins in the network lack a particular function is critical for function prediction with diffusion, and may contribute to accuracy advantages over other methods.
Our data implicate a catalytic ribonucleoprotein in transcription by Pol I and Pol III, whose coordinated function is critical for protein synthesis and cell growth.
