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Thus, the endosomal/lysosomal membrane is a barrier to entry into the intracellular space that must be overcome for therapeutics whose function is contingent upon interaction with the cytosolic cellular machinery.
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Differentiated hepatocyte function was contingent upon aggregate formation within the alginate microbeads.
In contrast, we employed RNA engineering to demonstrate deviation of G-quadruplex (GQ) function that is contingent upon its context dependent location, which is opposite to their native functional role.
The functional characterization of a protein from its sequence using in silico methods based on the 'sequence to structure to function' paradigm is contingent upon the availability of its 3D-structure.
Neural function under stressful conditions is contingent upon maintaining ion gradients across cell membranes, which are essential for neuronal signaling.
That is, the intention to use a new technology is contingent upon one's perception of organizational support and guidance.
Existing protocols for finite time consensus of MAS are normally based on the signum function or fractional power state feedback, and the finite convergence time is contingent upon the initial conditions and other design parameters.
Is survival benefit with upfront surgery in patients with PaCa largely a function of the patient factors including tumor size and LN status or it is contingent upon achieving a R0 resection surgically?
However, CD103 is not required for Treg cell function in the intestine in a T cell transfer model of colitis, although protection from inflammation is contingent upon non-T cell expression of CD103 [9].
For example, loss of function of Erg3 in the ergosterol biosynthetic pathway blocks the accumulation of toxic sterols and confers resistance that is contingent upon Hsp90-mediated stress responses (Cowen, 2008).
According to this scheme, sensory transmission in POm is contingent upon ongoing cortical L5 activity and the relative timing of sensory and cortical events (an "AND-gate" function).
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