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However, multiple mutations are often deleterious for the activity and the identification of all the residues that historically led to the function is complicated.
Measuring the relationship between hydration status and brain function is complicated by a lack of clear and consistent methods in altering and measuring hydration status, particularly with respect to inducing dehydration.
Moreover the relative contribution of each of these GEFs towards Arf6 function is complicated by the fact that most experiments are performed in the presence of other Arf6-specific GEFs.
Extrapolation of ovary-specific transcripts to oogenic function is complicated by maternal mRNA storage in oocytes during vitellogenesis.
These results show that the relationship between pain and NPS, as well as with physical function, is complicated and warrants additional longitudinal evaluation.
The study of toxic effects on small intestinal function is complicated by the integration of the activity of the small intestine with the activities of other regions of the GI tract.
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We do this for simplicity, as our utility function is complicate as it is now.
In case of double design variable, the histories of design variables and objective function are complicated, and the number of iterations is very sensitive to the initial values of design variables.
Attempts to define the processes through which HDACi influence cell function, are complicated by the fact that they usually inhibit several different members of the 18-strong HDAC family.
Studying isoform specific functions is complicated since databases rarely have isoform specific information.
Incorporating such multiple functions is complicated, requiring exquisite chemical control during production and rigorous characterization studies to confirm the compositions, structures, properties, and performance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com