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Although the etiology of NEC is incompletely understood, contributing factors are thought to include immature intestinal motility and barrier function, inappropriate initial gut microbial colonization and perinatal hypoxia/ischemia [76].
Despite its widespread use and popularity, this approach has disadvantages: the fitting of a polynomial function across a chromosome artificially increases spatial autocorrelation of recombination rate estimates, which renders most statistical analyses using multiple recombination rate estimates derived from this function inappropriate.
As ERα mediates mammary cell differentiation and function, inappropriate exposure of cells to estrogens or xenoestrogens might alter the behavior of an established neoplasia.
Because histone modifications are proposed to affect chromosome function, inappropriate histone modifications would be expected to result in dysregulation of cell growth, leading to neoplastic transformation or cell death [ 3– 6].
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Between 20% and 46% of prescriptions requiring dosage adjustments based on renal function are inappropriate.
Vitamin D deficiency also adversely affected vascular function by inappropriate activation of the RAS [ 40], and chronic inflammation [ 41].
The delay in elevation of creatinine to approximately 24 48 h after AKI makes this standard renal function test inappropriate for the early diagnosis of AKI.
In this situation, describing the PD of the entire population using a single function is inappropriate as response trajectories are different.
Methodological differences between these studies mean that direct comparison between the UK, USA and Denmark on the magnitude of the deprivation gap in lung function is inappropriate since the socioeconomic exposure measures used are different.
Moreover, ROS serve important physiological functions; thus, inappropriate removal of ROS may cause paradoxical reductive stress and thereby induce or promote disease.
However, it is reported that the original BPSO and its variants are unable to provide satisfactory results due to the use of inappropriate transfer functions.
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