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Although autophagy has a survival function in tumorigenesis of some cancer cells, autophagy may be important for cordycepin-induced MCF-7 cell death.
Present knowledge of lumicans' biology provides a fundamental platform upon which to build and deepen our understanding of lumican function in tumorigenesis in order to be able to design credible anti-tumor approaches.
Over the years, various studies have identified several modes of mitochondrial function in tumorigenesis.
As the field progresses, the importance of aberrant TCA cycle function in tumorigenesis and the potentials of applying small molecule inhibitors to perturb the enhanced cycle function for cancer treatment start to evolve.
Custerin function in tumorigenesis is unclear.
It, therefore, becomes important to identify the targets of DNMT3B in colon cancer cells to understand its function in tumorigenesis.
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These results, taken together, suggest that infection-associated inflammation has an important function in gastric tumorigenesis through the promotion of the Wnt/β-catenin activity beyond the basal activation level.
Unlike tumor suppressive E3 ligase such as FBW7 and FBXO4, or oncogenic E3 ligase such as SKP2, β-TRCP (β-TRCP1 and β-TRCP2) displays context-dependent (tumor type or cellular context) functions in tumorigenesis (Wang et al., 2014; Skowyra et al., 1997).
Networks 1, 4 and 6 of up-regulated genes were chosen according to the highest score value (23), the corresponding functions in tumorigenesis (proliferation, cancer and cell cycle) and the presence of the PIP gene, respectively (Table 7).
Therefore, the precise effects of Ras-related factors and their functions in tumorigenesis warrant further investigation.
Recent studies have shown that FHL1 also has important functions in tumorigenesis and cancer progression.
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