An attempt to remove the side chain of Arg 3 to introduce anchoring functions in this position resulted in a total loss of activity, whereas substitution of Arg 2 by ornithine (Orn) and its acylated derivatives gave a reduction of only one order of magnitude.
The function of this position 114 in the PA subunit has not been analyzed before, but may affect promoter binding [30], [31], [32], or may modulate endonuclease function [17], [28], [29], [30] since both these functions are mediated by the N-terminal domain of PA.
The pivotal function of a residue in this position also holds true in the rare instances when this Trp residue is replaced, e.g. by Phe in the human PAR1 [ 25].
This is not the case for Myo10's function in spindle position because expression of GFP-IQT in a control background has the opposite effect on spindle position to the Myo10 MO (basal rather than apical position), and the GFP-IQT rescue of the morphant phenotype restores rather than randomizes spindle position.
The nasals and liquids functioning as nuclei of syllables in this position (like the final sounds of English bottom, button, bottle, butter) are traditionally written m̥, n̥, l̥, r̥.
If someone reaches a point where they are no longer able to function in their position, it's important to take care of them - to provide health insurance and give them a healthy 'package.'package
Together, we believe that these results reflect the microtubule rather than actin dependence of Myo10 function in spindle position.
The first sign of respiratory involvement in these patients is decreased pulmonary function in supine position, eventually necessitating respiratory support during sleep.
This suggests that Dlg3 might have a conserved function in spindle/BB positioning (Johnston et al., 2009).
Compounds possessing a carboxylic acid function in the appropriate position showed improved oral exposure (AUC) relative to the initial chemical leads without reduction in the antagonist activity.
Information about introns in the sequences were taken from "CDS" feature lines with a "join" function in the feature position.
