However, molecular imaging approaches based on a single probe may be insufficient, especially as alternative pathways may replace the function of the targeted pathway [7, 8], resulting in a false negative test outcome.
But even a molecular imaging approach based on a single probe may be insufficient, as alternative dysregulated signal pathways may replace the function of the targeted pathway [93, 94].
Such unexpected responses in pathways remote from the targeted pathway can be challenging to explain.
1121 genes were predicted to function in the same pathways as those examined in our study.
We hypothesized that these 253 proteins function in the same signaling pathways as their orthologs.
NADP+ is a closely related compound functioning in biosynthetic pathways as well as redox homeostasis.
Alterations in genes functioning in the same biochemical pathways as BRCA1 could effectively result in loss of BRCA1 function [ 9].
The ubiquitin proteasome pathway plays a key role in the targeted destruction of cellular proteins and is central for cell cycle, function and survival, making proteasome inhibition an attractive target in cancer [ 1– 4].
ROS-driven pathways likely function in stromal cells as well as tumor cells.
We, therefore, speculate that it could as well function in the siderophore mediated iron uptake pathway.
MO activities in zebrafish embryos include both sequence-specific RNA binding as well as effects not associated with loss of function of the targeted locus [ 3, 6, 17 19].
