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ERK is considered to be an essential function in the proliferation and differentiation of osteoblasts [ 39, 40].
EGFR family members have a critical function in the proliferation, migration, survival, and differentiation of target cells.
MEL1 is described to have an essential function in the proliferation and maintenance of hematopoietic stem cells [ 47].
Recently, it has become evident that adenosine A2A receptors may function in the proliferation and differentiation of mouse bone marrow-derived mesenchymal stem cells (BM-MSCs) [ 20].
It is probable that the ERK (extracellular signal-related kinase) pathway induced by G-CSF has a major function in the proliferation and differentiation of neutrophils.
Estrogens, which are elevated during pregnancy, could have a function in the proliferation of malignant thyroid cells (Glinoer et al, 1990; Manole et al, 2001).
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Since MAPK inhibitor, PD98059, significantly inhibited the proliferation stimulated by LPA, which suggested ERK/MEK/MAPK pathway was involved in the LPA functions in the proliferation in Hela cells, we investigated whether LPA can activate the phosphorylation of ERK.
In line with securin function in mitosis, the proliferation marker Ki-67 displayed the same expression pattern as securin and nuclear β-catenin, indicating high proliferative activity of these tumour cells.
RNA interference was used to test the requirement for MEK1 and MEK2 function in maintaining the proliferation of human colorectal cancer cells.
Specifically, recent studies indicate that those miRNAs that are selectively and/or highly expressed in immune cells including the miR-17 92 miR-17 92miR-150, miR-155, miR-181 and miR-223 have a 'permissive' funclustern the maturation, proliferation and differentiation of myeloid and lymphoid cells.
Among them, FST is known to be one of the most important, and plenty of studies have highlighted its functions in promoting the proliferation and differentiation of myoblasts [ 5, 23].
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