For clarity, other meiotic factors that are known to perform important functions in the organisation of the chromosome axis, such as SYCP2, cohesin and condensin, are not depicted.
The laminin-binding integrins are potential therapeutic targets for inhibition of metastasis, but they also fulfil critical physiological functions in the organisation and maintenance of epithelial cell layers.
The two proteins that were identified in our screen, however, are completely uncharacterised in terms of function and their role in the organisation of the early secretory pathway needs to be addressed.
Although we do not know the exact reason for this, there are several plausible explanations: First of all, health selection may be at work: the most fragile ambulance workers health-wise may have changed job function internally in the organisation resulting only in the most healthy ambulance personnel remaining.
The transmembrane receptor Notch and the epidermal growth factor receptor EGFR also seem to play an important role in the organisation, remodelling and function of the olfactory system [Additional file 5: Supplemental Table S4].
In addition to such a rational organisation, however, there is a need to establish some sort of informal organisation; i.e. a common culture or identity that would function as "glue" in the organisation.
The work described here has yielded the first atomic view of an SC protein, the lateral element component SYCP3, and has provided a molecular basis for SYCP3 function in the compaction and organisation of the meiotic chromosome.
It is crucial to develop a relationship with the right individual at the organisation you're trying to work with, both in terms of their function within the organisation and their position in the hierarchy.
However, an absence of ISP3 alters the apical localisation of ISP1 in all invasive stages including ookinetes and sporozoites, suggesting a coordinated function for these proteins in the organisation of apical polarity in the parasite.
Improvements in individual health and social group outcomes are known to contribute to the function of the organisation [3].
