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Testing of these hypotheses will require further examination of gene function in the context of gene duplication patterns in species exhibiting various nodule characteristics across the legumes.
We anticipate that an inter-disciplinary approach, combining biological experiments with physics and mathematics, will be essential to unravel how graph structure gives rise to function in the context of gene regulation.
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A number of factors potentially related to gene function such as sequence identity, gene phylogenetic profiles, sequential genomic co-localizations, gene expressions, and protein-protein interaction have been investigated in the context of gene function prediction and analysis [ 3– 8].
This argument has been previously made in the context of gene function prediction [ 17].
A number of factors have been investigated in the context of gene function prediction and analysis, such as sequence identity, gene expressions, and gene co-evolution.
This is particularly important in the context of gene pleiotropy whereby a single gene regulates more than one biological function (Beckers et al., 2009).
Although sirtuins were initially studied in the context of gene silencing and aging, in mammalian cells, many other biological functions have been revealed.
In addition to analyzing genes in the context of gene families, a further analysis of gene names was performed in the context of duplicated genes that may share similar or identical functions.
A current challenge in gene annotation is to define the gene function in the context of the network of relationships instead of using single genes.
Thus we should account for such diurnal oscillation when considering gene function in the context of biological pathways.
However, cell-cycle regulation involves a large, highly redundant, set of genes, which complicates unravelling of function in the context of a higher plant.
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