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Because no structural data currently exists for a protozoan glutaminyl-tRNA synthetase (QRS), an understanding of its potential as a drug target and its function in the assembly of the Toxoplasma multi-aminoacyl tRNA (MARS) complex is therefore lacking.
While the SMN protein has been shown to function in the assembly of RNA-protein complexes, it is unclear how the overall reduction in SMN activity specifically results in the neuromuscular phenotypes.
DOI: http://dx.doi.org/10.7554/eLife.01641.013 The observations presented above suggest two possible hypotheses for how Ki-67 could function in the assembly of the chromosome periphery.
Once the Z-ring is established, ZapA binds to the ring where it has perhaps a weak structural function in the assembly of the divisome.
Although p21 and p27 inhibit cyclin E-cdk2, they also function in the assembly and activation of cyclin D-cdk4 and cyclin D-cdk6 complexes.
We further examined the ability of the chromatin remodeling-defective Chd1 proteins to function in the assembly of periodic nucleosome arrays.
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We introduce a case study that illustrates how the proposed method works and helps to reduce the number of functions in the assembly process.
SMN together with Gemins2-8 and unrip proteins form a macromolecular complex that functions in the assembly of small nuclear ribonucleoproteins (snRNPs) of both the major and the minor splicing pathways.
This may seem odd at first glance, but SMN together with other proteins functions in the assembly of small nuclear ribonucleoproteins (snRNPs), which are critical for pre-mRNA splicing [46], [47].
More than 96% of affected individuals demonstrate a homozygous deletion/mutation involving exon 7 in SMN1 (survival motor neuron 1), resulting in the biochemical deficiency of the SMN protein, part of a complex that functions in the assembly of small nuclear ribonucleoprotein particles (snRNP) [7], [8].
However, there is no evidence that it directly functions in the assembly of clathrin-coated vesicle.
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