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Such disruptions, resulting from both genetic and environmental factors, can affect overall renal function in postnatal life.
Although IGF-II has a clearly established role in foetal development (Allan et al, 2001), its function in postnatal life is less understood, despite circulating at a much higher concentration than IGF-I.
Overall the differences revealed by deformation analysis suggest a deviation from the normal organ development at the end of embryogenesis, which could lead to altered organ function in postnatal life.
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Based on the prominent effects of EPO on cognition, we hypothesized that an important physiological role of EPO in postnatal life or adulthood might be the modulation of neuroplasticity and of higher cognitive functions.
However, a relatively smaller left ventricle and aortic root may lead to insufficient cardiac functioning for increasing metabolic demands in postnatal life.
Our results, however, show that Noto-cre is detected in the tail but also throughout the axial spine to the upper thoracic region, thereby demonstrating the potential of this mouse to explore the phenotype and function of notochordal cells during development and in postnatal life, including the generation of notochord-specific gene knockouts.
Overall, these growth alterations could be indicative of underlying functional, physiological alterations which could become apparent in postnatal life.
To account for environmental exposure to lead in postnatal life, we also modeled MDI as a function of the child's blood lead concentrations at 24 months of age.
Terminal differentiation occurs not only in embryonic development but also in many tissues in postnatal life.
We have previously shown that offspring of dams fed a high fat diet throughout life (including during pregnancy and lactation) show accelerated weight gain in postnatal life, independent of postnatal diet [58].
The characteristic FD lesions in mice developed only in postnatal life as in human FD [ 6].
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