Sentence examples for function in lifespan from inspiring English sources

Having established that the presence of a functional Grb2/Drk-binding site in Chico is required for its wild-type function in lifespan, we tested whether ectopic activation of Ras can block the beneficial effects of chico mutation on lifespan.

These results show that SMG-1 requires DAF-16 and DAF-18 to confer oxidative stress resistance as well as to function in lifespan control.

As GFP expression was very pronounced in the pharynx (Supplemental Figure 4A-F) we addressed whether this tissue is important for mir-71 function in lifespan modulation.

Furthermore, the a-subunit of AMPK, encoded by aak-2, functions in lifespan, dauer formation and stress responses [49], [50], [51], [52].

Although we cannot rule out the possibility that other AGEs are unaffected or that small suppression of CML can have a dramatic effect on lifespan, our data suggest that DAF-16 may have other functions in lifespan regulation downstream of RIF, apart from detoxifying and disposing AGE-modified proteins.

Therefore, E + ( t ) is an increasing function in the lifespan.

Inactivation of Sir2 enhances stress resistance and extends chronological lifespan of nondividing yeast cells, which is opposite to the requirement for Sir2 function in the reproductive lifespan [ 7].

To gain insight into the function of Ot B in lifespan extension, we examined the effect of Ot B on lifespan of the long-lived insulin-like receptor mutant daf-2 e1370) daf-2 e1370

These modifications, known as the storage lesion, lead to alterations in the function and lifespan of RBC in vivo post transfusion [ 3, 4], which can have detrimental side effects in the recipient [ 5].

Such correlations may explain aspects of lifespan evolution, and why loss-of-function mutants can result in lifespan extension.

If the role of SMG-1 in lifespan relies on its function in NMD, inactivation of other smg genes should also have an effect on lifespan.