Sentence examples for function in life span from inspiring English sources

Based on our results, we propose a hierarchical model of DAF-16/FoxO isoform function in life span control.

To illuminate the mechanistic basis for DAF-16/FoxO isoform-specific functions in life span control, we performed whole transcriptome profiling of young adult daf-2 (e1370 ) mutant animals in the context of wild-type daf-16 /FoxO and isoform-specific daf-16 /FoxO mutant alleles.

Whether the localization of Pnc1 to peroxisomes is important for its function in life-span extension is not yet known.

This discrepancy may be a consequence of distinct experimental strategies used to assess the function of DAF-16/FoxO isoforms in life span control.

Our results define new functions for DAF-12 complexes in life span control and underscore the context-dependence of these activities.

While this might be attractive as a possible mechanism for the life span decrease observed in p53-over-expressing females, it is not consistent with the life span increase observed in males; indeed other experiments involving disruption of adult diploid cell function caused an equally dramatic decrease in life span in both sexes [ 35].

The loss of sip-1 function in C. elegans results in embryonic lethality and reduction in life span [ 37].

The set of common DR induced genes found represents genes important in life span extension as well as genes associated with other nutrient induced physiological functions not directly related to life span, such as decreased fertility.

Nicotinamide strongly inhibits Sir2, a protein important for life-span extension by calorie restriction (Kaeberlein et al. 1999), and, like Sir2, Pnc1 also functions in life-span extension (Anderson et al. 2003).

This is equivalent to a 10% decrease in life span.

In addition, infection led to significant reductions in life span.