Exact(6)
These proteins are referred to as chaperones or stress proteins because they exhibit a critical function in assisting newly synthesized polypeptides (clients) in achieving functional conformation, localization, activation and oligomerization.
Owing to its unique function in assisting the release of newly formed virus particles from the surface of an infected cell, neuraminidase, an antigenic glycoprotein enzyme, is a main target for drug design against influenza viruses.
MRAP appears to have an important additional function in assisting ACTH binding and consequently signal transduction (3, 4).
The non-classical class II DM molecule, HLA-DM in the case of humans, possesses critical function in assisting the classical MHC class II molecules for proper peptide loading and is highly conserved in tetrapod species.
BLAST analysis of the transcriptome data obtained in this study against the public databases revealed the presence of some RNAi core machinery elements such as Argonaute-2B, Dicer-1, SID-1 and also TAR RNA binding protein (TRBP), which function in assisting the RISC formation (data not shown).
The latter together with the lasting debate over sperm quality and density decline [ 4– 7] intensifies the need for accurate and rapid evaluation of sperm function in assisting clinical decisions, that is, whether natural conception is feasible or medical support should be sought for reproduction, taking the age of the woman and the duration of infertility into account.
Similar(54)
These results suggest that FGF-9 functions in assisting mesenchymal cells to closely re-integrated, similar to a tissue layer.
Macrophages have been attributed functions in assisting invasion, promoting angiogenesis and subverting an immune response to the advantage of the tumour.
This finding indicates that saposin B does have in vivo functions in assisting α-galactosidase A and the β-galactosidase(s) involved in Gb3 and LacCer degradation, respectively, but these roles are minor in most tissues.
Similarly, it has been proposed that TCP-1 interacts with the proteasome and facilitates the degradation of TCP-1 substrates that have misfolded; the TCP-1 complex functions in assisting protein degradation through interaction with the proteasome.
Several authors hypothesized that toxins secreted by the infralabial glands of Dipsadini are probably used in some envenomation function or in assisting in the detachment of the snails from their shells [ 10, 14, 38, 39].
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