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Almost every chemical concept is assigned at least two types, generally one from the structure hierarchy and at least one from the function hierarchy".
Note that in GO function hierarchy, some genes/transcripts belong to multiple categories.
We only considered the biological function hierarchy, and used a minimal GO path length of five.
Altogether these results point to a crucial role for both antigen potency and effector function hierarchy in determining the degree of co-receptor dependency of antigenic stimulation.
AUC: Area under the receiver operating characteristic curve; BP: GO biology process hierarchy; EPCs: Endothelial progenitor cells; GO: Gene Ontology; kNN: k-nearest neighbors; LOOCV: Leave-one-out cross-validation; MF: GO Molecular function hierarchy; SVM: Support vector machine.
This was done to emphasize the involvement of genes in entire, well-defined biological processes rather than in unique "activity" terms, as defined in the molecular function hierarchy (MF).
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It also became apparent that the level of functional annotation captured by the GCI scoring model increasingly paralleled GO molecular function hierarchies the deeper a gene's functional characterization reached.
"We're using a non-semantic neural topic modeling approach with a heuristic function for hierarchy building," says Schjøll Brede.
Under the Molecular Function GO hierarchy (Additional File 4), assignments were mainly to catalytic and binding activities.
The origins and functions of hierarchy in capitalist production, Part I". The Review of Radical Political Economics 6 (2): 60-112.
By the 18th century, viceroys served average terms of five years, and under them functioned a hierarchy of bureaucrats, nearly all sent from Spain to occupy frequently lucrative posts.
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