Understanding the degree to which avoiding AKI preserves longer term kidney function has broader implications for the acceptability of side effects and costs of interventions which prevent AKI.
For instance, chimeric proteins bearing this sequence could be potentially used for delivering bioactive components to the endo-lysosomal compartment to modulate lysosomal function, which has broad implications for cell viability, both in carcinogenesis and degenerative processes.
Thus, mRNA transport appears to be an important function of trafficking Rab5a-positive endosomes, particularly during filamentous growth (Fig. 3D and E ., This novel function of endosomes has broad implications for mRNA transport in general.
Given its importance as the ultimate decoder of the genetic information, understanding the ribosome's function and regulation has broad implications.
Additionally, for loss-of-function analysis of rice, the RiceGE database (http://signal.salk.edu/cgi-bin/RiceGE) is very useful and has broad functions.
Ntn-1 has broad functions and regulates many biological processes, including cell proliferation, differentiation, and the determination of cell fate, although Ntn-1 was originally thought to participate in the formation of axon.
GO analysis of mA-containing mRNA transcripts reveals that mA-containing transcripts are involved in many functional categories, indicating that mA has broad and fundamental functions [24].
This may be further explained by the notion that each transcription factor has broad developmental functions beyond mitochondrial biogenesis and respiratory functions, as NRF-1 and NRF-2-null mice display pre-implantation lethality (Huo and Scarpulla, 2001; Ristevski et al., 2004).
DC-SIGN has broad physiological functions.
Catechol- O-methyltransferase (COMT) enzyme has broad biological functions, principally the catabolism of biologically active or toxic catechols, including catecholamines and catecholestrogens [ 1].
