PAK1 is a serine/threonine kinase downstream of small GTP-binding proteins, Rac1 and Cdc42, and is an integral component of growth factor signaling networks and cellular functions fundamental to tumorigenesis.
Finally, because severity of distress influences ratings on the WAI we also report associations between the scale and a range of standard measures of symptoms, illness severity and level of functioning fundamental to psychotic disorders.
Defining relevant pathways regulating p53 function are fundamental to an understanding of its tumour suppressor role and mechanisms of p53 inactivation, which might be independent of a p53 mutation.
Definitions and how they function are fundamental to philosophy.
In particular, disabled dendritic cell differentiation, maturation, migration, and function are fundamental to this defect, as they are the most potent antigen-presenting cells (APCs) of the immune system, interacting with T and B lymphocyte as well as NK cells to induce and modulate immune responses.
Furthermore, as some proteins and/or cells appear to respond variably to over expression levels, access to single cell data linking transcription factor levels to function is fundamental to improved mechanistic understandings.
Their molecular cargo is cell specific [ 68], regulated by tissue physiology and cellular function, and fundamental to their bioactivity.
Since immune cell function is fundamental to keep the organism under imnological surveillance during the defence against pathogens, to investigate the effects and possible molecular mechanisms of altered gravity is indispensable for long-term space flights to Earth Moon or Mars.
Answering that question will help demonstrate what functions are fundamental to life, if not how many genes they require.
Deciding which attributes to track in order to capture ecosystem-scale changes in status and contextualizing the values of measured attributes relative to desired ecosystem states and functions is fundamental to EBM [1], [4].
