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Function: enriched GO category or pathway.
Copper ion binding (GO 0005507) is another molecular function enriched in the secretome.
In the GO domain of "molecular function", enriched GO terms were "cytoskeletal protein binding" and "GTP binding".
When seeking functions enriched by the other clustering methods, the only function enriched was "NAD biosynthesis" (p < 10-5) discovered by CLICK.
We applied ortholog interactomes, expression data, shared biological function, enriched domain pairs, gene neighbor, gene fusion and phylogenetic profile combined with prior odds to predict protein-protein interactions.
While the most significant biological function enriched in late HSRs is again the 'response to stimulus', 'embryonic development' and 'seed dormancy' are also among the GO-function categories significantly enriched (Additional files 7, 8, 9, 10).
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GO enrichment analyses identifies biological functions enriched in each cluster (Additional file 1: Tables S12 S17).
The functional analysis results showed that the functions enriched in module 3 were primarily related to "cell death".
Biological functions enriched in the differentially expressed genes were identified using modular enrichment analysis with DAVID (Database for Annotation, Visualization and Integrated Discovery) [ 19, 20].
Further bioinformatic mining revealed network categories and molecular functions enriched by the NP truncation mutant that included Hematological Diseases as the most enriched network function (Table 1).
To better understand biologic functions enriched in the SAE transcriptome, the gene lists were assigned to functional categories using Gene Ontology molecular functions and the expression levels for ubiquitous and SAE-enriched genes were compared.
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