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Gene-modified (GM) mice are essential resources for studying gene function, developmental processes, and human diseases [ 1, 2].
In addition to genes that encode predicted transcripts of unknown function, developmental genes feature prominently among the latter.
Ontology term enrichment analysis (Biological Process and Molecular Functions GO terms) of the 302 over-expressed uterine transcripts showed that the most over-represented proteins are related to reproductive function (developmental processes, morphogenesis…) (Additional file 3, Figure 2) in agreement with the observation of Jeong et al. [ 44].
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Furthermore, peptidases that are expressed during development might function in developmental signaling by acting on developmental signaling molecules or extracellular structural proteins (Fong and Bonner, 1979).
The distinction between biochemical (activity) function and developmental (use) function is reinforced by the hierarchical aspects of homology (Hall 1994).
Driscoll and Strupp reviewed the value of serial reaction time operant methods for assessing executive function in developmental neurotoxicity studies.
It is not entirely understood whether these structural changes are secondary to modifications in the function of developmental genes and how they are inflicted on a mechanistic basis.
Until recently though, little research has evaluated the effects of isoflavones on immune system function, says developmental biologist Paul Cooke of the University of Illinois, Urbana-Champaign.
However, comparatively little is known about Cul-5 function in developmental and morphogenetic processes.
Our results revealed specialization between two midgut-specific chitinase genes, AgCht8 and AgCht13, as a function of developmental stage.
Unlike the stable nuclear Bcd concentration profile, target gene expression patterns evolve significantly as a function of developmental time.
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