Exact(29)
The next question to answer is whether the residues in W-patterns are conserved for function conservation.
In this study, we successfully employed our previously developed function conservation approach [ 22], to predict functional TF pairs from tissue-expressed genes in 79 human tissues.
And indeed, orthology alone is no guaranty of function conservation: many cases are known where orthologs have diverged functionally [ 28].
This protein may thus represent an extreme example of olfactory function conservation.
These are obviously approximations and notably, a recent study failed to support a correlation between sequence and function conservation [ 23].
Structural function conservation and key residues in the query proteins were identified by ConSeq server (http://conseq.tau.ac.il).
Similar(31)
Predicted protein sequence encoded by timeless in Ae. aegypti and D. melanogaster were highly similar in domains of known function, suggesting functional conservation.
Moreover, the relationships within a group of orthologues constitute the basis for a better understanding of the evolution of ancestral functions (conservation versus neo- or sub-functionalization through duplication) [64] [66].
Any adequate evaluation of these cases must recognize a more fine-grained decomposition of genes into working units to capture genuine activity-function conservation.
Sites selected by UNESCO's Man and the Biosphere (MAB) Program for inclusion in the biosphere reserve network are intended to carry out three basic functions: conservation, development, and logistic support for research, education, and monitoring.
The precursors, expression levels, miRNA* sequences, target functions, conservation, and evolution of miRNAs we identified were investigated.
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