We defined the following combining functions: Concordance function: WCON = SGM × Sperf, identifies regions of concordance between GM atrophy and hypoperfusion.
Functional concordance was then measured as a binary quantity, corresponding to whether or not a putative orthologous sequence had the same inferred function as its cognate human sequence.
The analysis includes first, the design of combining functions of concordance or discordance between GM atrophy and hypoperfusion, followed by permutation tests to obtain the distribution of each combining function and to perform a statistic.
The results showed no effect of sexual functioning on concordance for either men or women, but the absolute correlations were also notably lower than those obtained for men and women in the other studies included in this meta-analysis.
Concordance function: WCON = SGM × Sperf, identifies regions of concordance between GM atrophy and hypoperfusion.
We postulated that true positive variations could be largely determined as a function of the concordance level; i.e., variations with very high concordant values would be true positives.
The leukocyte index, consisting of genes predominantly associated with immune function, displayed strong concordance with pathological assessment of immune cell infiltration.
For statistical inference of the concordance function, we set the critical threshold of T-values for concordance to a value equivalent to the joint distribution of atrophy and perfusion at p < 0.05 statistical significance with a family-wise error (FWE) adjustment for multiple comparisons, as illustrated in Fig. 1.
Consequently, patients with co-morbid substance abuse have a higher rate of re-hospitalisation, reduced psychosocial functions, less patient concordance with treatment, as well as a higher relapse rate than patients without such substance consumption [23].
The statistical analyses were completed using descriptive statistics (SPSS 10.0) and Lin concordance functions [ 10] (STATA Rel. 7.0).
