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Invertase secreted from S. cerevisiae cells resides mainly in the cell wall to perform its physiological function, cleavage of sucrose molecules diffusible into the cell wall (Nam et al. 1993).
In addition to loss of WT Htt function, cleavage of the mutant Htt could also generate toxic N-terminal fragments that are amyloidogenic [4].
Reducing conditions restore zinc-finger function, cleavage and homing fidelity.
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One valid conclusion, in view of the complex biology of APP function and cleavage, is that APP and presenilin mutations cause AD because they alter several cleavage products of APP, which each in turn contribute to AD.
To function, Rnt1p cleavage products only need protection from exonucleases and a target sequence to cleave.
These results imply that the enzyme has been continually changing during evolution while still maintaining its function in cleavage of the mid-ZPd site.
Cathepsin K is a member of the papain family of cysteine peptidases with a primary physiological function of cleavage of type I and type II collagen [ 58].
Afterwards, they are translocated to the nucleus to perform their function by cleavage of poly(ADP-ribose) polymerase – PARP or other proteins such as chromosomal passenger complex members.
Regardless, an alternative interpretation is that a life-long change in APP function and cleavage could protect against AD independently of lowered Aβ production.
Although decreased β-secretase processing of many BACE1 substrates impairs their function, abrogated cleavage of other substrates may potentiate their role in a physiological process.
Gap junctional communication has been previously involved in Xenopus left-right (LR) development, however a function at cleavage stages was inferred from inhibitor experiments.
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