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In this way, it allows more alternative ways of function assignments, and if a function is assigned in spite of all those possibilities, we can consider it to be a genuine function, with more certainty.
Among the molecular function assignments, a high percentage of genes were assigned for Binding (49.1%), predominantly heat shock proteins (Hsp).
The completeness of these reconstructed pathways indicates that the gene function assignments were biologically meaningful and that the EC numbers have been correctly assigned to annotated sequences.
General loss function assignments transform sequential prediction problem into a decision problem [20, 27].
In this step, we were able to predict function assignments for 1546 human proteins, but with lower accuracy of 90%.
The result is a set of putative structure and function assignments including a novel statistical measure of reliability (Shindyalov et al. unpublished).
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A necessary prerequisite for implementing such approach is rich gene annotation covering from domain and function assignment to aggregate properties as functional category or pathway membership.
Assuming all the protein functions in the test set are unknown, we assign those functions based on our function assignment method; the results are shown in Table 2.
Schork et al. [ 46] used a relatively simple SNP function assignment method based on considering the functional setting of SNPs in LD with GWAS markers and looking for category enrichment for 14 complex traits.
Importantly, the characterisation of gene products with previously unknown functional properties through community detection has the potential to aid function assignment.
Such functional diversity within a homologous protein family presents a significant challenge for bioinformatic function assignment.
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