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These proteins function as switches that adopt different conformations in the GDP- and GTP-bound states [6] [7] [8].
Since phosphorylation of serine, or presumably also threonine, can prevent or even disrupt binding of effector proteins (e.g. heterochromatin-binding protein 1, HP1) at adjacent methylated lysine residues, it can be assumed that such sites could also function as switches regulating the chromatin signature [ 26, 27].
It is well accepted that changes in protein abundance and post-translational modifications can function as switches in the interactome and a viral infection of a cell can fulfill, perhaps more than any other condition, the requirements for the dynamic perturbation of the cell's interaction network, a situation believed to be central in the development of disease.
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Rho GTPases function as switching molecules to converge both extracellular and intracellular signals in regulation of cytoskeletal organization.
FadR functions as switch between fatty acid β-oxidation and fatty acid biosynthesis (Xu et al. 2001).
Such channels could provide a path for light to follow in an optical computer chip or could function as optical switches.
The CPU and RAM are integrated circuits (ICs)—small silicon wafers, or chips, that contain thousands or millions of transistors that function as electrical switches.
Such allosteric proteins could function as novel switches in complex circuits, metabolite sensors, or as orthogonal regulators for independent, inducible control of multiple genes.
Autophosphorylating histidine protein kinases provide phosphoryl groups for response regulator proteins which, in turn, function as molecular switches that control diverse effector activities.
RNA and DNA molecules can be engineered to function as molecular switches that trigger catalytic events when a specific target molecule becomes bound.
Rho guanosine triphosphatases (GTPases) are a family of small proteins which function as molecular switches in a variety of signaling pathways following stimulation of cell surface receptors.
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