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ZNFs are important compact structural motifs that are known to function as interaction modules (Kochańczyk et al., 2015).
However, based on pairwise assays [ 38], GSQUA proteins seem unlikely to function as interaction mediators in Gerbera, since their interaction capacity appears to be limited [ 38].
A prime challenge in developing such strategies is to understand how genes function as interaction networks to carry out and regulate cellular processes, and how perturbations in these cellular networks cause certain phenotypes, such as human diseases, in some individuals, but not in the others.
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Loss-of-function genetic analysis plays a pivotal role in elucidating individual gene function as well as interactions among gene networks.
The gene products are designated as ATIPs (angiotensin II AT2 receptor-interacting proteins) or as ATBPs (AT2-receptor binding-protein) and the name is derived from their function as interaction-partners of AT2-receptors of the renin-angiotensin-aldosterone system.
Understanding the intestinal bacteria in ruminants and their population kinetics is essential for their ecological function, as well as their interaction with the host.
Thus, the impact of NP under current and future exposure scenarios (including co-exposure to other stressors) on communities, ecosystems, ecosystem functions as well as interactions across ecosystem boundaries deserves special attention.
In addition, we show that these genes had overlapping but distinct functions, as well as interactions at the transcript level with AtPHT1 7 and other genes that are involved in controlling P nutrition.
Two of the MBD1 ZF-CxxC domains (CxxC-1 and CxxC-2) are type-2 domains which lack a functional DNA-binding loop [ 95] and instead appear to function as protein protein interaction modules [ 98, 99].
All five domains appear to function as protein interaction modules mediating associations of SAP scaffolds with their multiple interacting partners [11].
This common expression in epithelial breast cells and in myeloid cells might be related to common biological functions such as interaction with extracellular matrix which precedes cell migration, a normal function of macrophages and an abnormal function expressed or amplified in human cancer epithelial cells.
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